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Semaglutide activates receptors of the hormone GLP-1 (glucagon-like peptide-1) while tirzepatide activates that hormone as well as a similar one called GIP (glucose-dependent insulinotropic polypeptide) to reduce appetite and food intake
PMID: 35658024
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In parallel, theres a focus on minimizing the rebound increase in body weight that patients might experience after stopping semaglutide
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These patches often cost $30-100 monthly without insurance coverage or proven benefit, diverting resources from effective interventions
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