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In 1922, Frederick Grant Banting and John Macleod discovered insulina peptideand its potential as a therapy for diabetes
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Other contributors include faulty axonal transport, resulting in buildup of neurofilaments and synaptic breakdown (Taylor et al., 2016), and genetic mutationssuch as SOD1 (causing harmful protein accumulation), FUS (interfering with RNA handling), and TBK1 or OPTN (which impair the cell's waste disposal system known as autophagy
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It plays a role in lipid metabolism by transporting long-chain fatty acids into the mitochondria and is a popular supplement for weight loss and fat burning
Epilepsia 1993, 34: 332-346
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