Added from other targets, the medication for patients would be complex, and the adherence would be low due to the large number of different kinds of medicines
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Although these compounds displayed lower activity than conventional drugs like Vildagliptin and Sitagliptin, two of the newly synthesized compounds showed potential DPP-4 inhibitory effects at a concentration of 10 M
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Similarly, excessive caffeine intaketypically defined as more than 400mg per day (roughly four cups of brewed coffee) according to Food Standards Agency guidancemay cause side effects such as jitteriness, sleep disturbance, or increased heart rate, which could indirectly affect adherence to a healthy lifestyle
Median follow-up time of these studies ranged from 1.6 to 5.4 years