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We definitely do see a slight change compared to the total population, Furner told Bloomberg in an interview

Often, adjusting the dosage or administration frequency can counteract these side effects

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When used for type 2 diabetes, the dosing recommendations are: Immediate-release tablet: 500 mg once or twice daily, or 850 mg once daily Extended-release tablet: 500 mg1,000 mg once daily For weight loss, PCOS, gestational diabetes, or other off-label uses of metformin, the dosage varies but most people start at 500 mg