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The combination may produce better outcomes than either alone, though this has not yet been studied in controlled trials
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The medicine is virtually non-toxic and has very few drug interactions
Under normal conditions, NNMT activity can consume substantial amounts of both nicotinamide and SAM, particularly in metabolically active tissues or during periods of metabolic stress
In these cases, a maintenance injection is often needed every 2-3 months to keep levels stable, as the body cant consistently source it otherwise
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