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Factors that could cause or contribute to such differences include, but are not limited to: (1) Regulatory and governmental approvals: The approval process for pharmaceutical products is subject to extensive regulations and may involve uncertainties and delays

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Obese mouse models (Coskun 2022) show basal energy expenditure +8-12% vs vehicle, a major contributor to the magnitude of weight loss observed in phase II clinical trials

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Combining these medications is not recommended

CONTRAVE may cause serious side effects, including: Seizures