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Novo immediately threatened to sue, and then the FDA said that it plans to take decisive steps to limit access to the active ingredients in popular GLP-1 drugs like Wegovy, Ozempic and Zepbound

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Thus, adding an additional commercially available drug, such as B12, is insufficient to justify compounding a GLP-1 medication

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The early concern that GLP-1 causes thyroid cancer has lead to extensive investigations and studies looking at this issues and to date there has been nothing to suggest a concern despite millions of people being treated with GLP-1 therapies around the world

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This is somewhat unsurprising, given the fact that persistently elevated androgen levels in PWA rodents have been shown to prevent ovulatory rescue after administration of more proxy activators of the reproductive axis, such as kisspeptin 46

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