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NRF-2 possesses six Neh (NRF2-ECH homology) domains, in which Neh1 is a bZIP structure that works for the dimerization of NRF-2 and its binding to DNA [17]
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reported that sulforaphane exerted a neuroprotective effect in a 6-OHDA-induced acute mouse model and attributed it to the ability of sulforaphane to enhance glutathione levels and its dependent enzymes, to up-regulate Nrf2 and to modulate the ERK1/2 pathway in the brain 28
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