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From the above experiments, total enzymatic rates (actual enzymatic plus non-enzymatic rates) were obtained
Safety and tolerability outcomes comprised discontinuation of treatment due to adverse events, incidence of serious adverse events, all-cause mortality, hypoglycaemia (plasma glucose 3.9 mmol/l), severe hypoglycaemia (a hypoglycaemic event requiring assistance), nausea, vomiting and diarrhoea
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Additionally, these medications enhance glucose-dependent insulin secretion from pancreatic beta cells whilst suppressing inappropriate glucagon release, thereby improving glycaemic control in individuals with type 2 diabetes