Glutathione levels in the body can be depleted by poor diet, environmental toxins, and stress
PMID: 10744677 Yang Y et al
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Yes, glutathione soaps can be effective for reducing dark spots, but results vary depending on the cause and depth of pigmentation
While often discussed for its aesthetic benefits, this is really a reflection of internal cellular health
"Glutathione in foods listed in the National Cancer Institute's Health Habits and History Food Frequency Questionnaire." Nutr Cancer