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They are all small molecules which act as reversible competitive inhibitors of the catalytic activity of DPP-4 and, when used at the appropriate therapeutic dose, are associated with at least 70% inhibition of plasma DPP-4 activity (35) (although the actual extent of inhibition in vivo is likely to be higher, due to dilution of the inhibitor in the ex vivo assay)
One is due to slowed gastric emptying
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Many users report that initial gastrointestinal effects diminish over time, but this is not universal
Tirzepatide is in a class of medications called glucose-dependent insulinotropic polypeptide (GIP) receptor and glucagon-like peptide-1 (GLP-1) receptor agonists
Include fruits rich in fiber like berries and apples to promote satiety and enhance GLP-1 production
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