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Some people might experience a gradual decrease in appetite over the first few days, while others may notice a more immediate reduction

The authors thank all volunteers for their participation in the study and Rachel Goldberg, Cindy Guandalini, and Mary Savoye for their help in the Yale Pediatric Clinic

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Combination therapy increases the frequency of required lab monitoring: baseline metabolic panel, liver enzymes, lipids, and glucose every 46 weeks initially

Supplementary information This file contains Supplementary Tables 1-3

Pratley, MD, medical director of Advent Translational Research Institute and AdventHealth Diabetes Institute in Orlando, Florida