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In the future, a multidimensional line of evidence is needed to clarify the source of GLP-1RA effects in IBD, including in vitro experiments to confirm direct actions, animal models designed to exclude metabolic interference, and clinical data adjusted for metabolic confounders

Polex-Wolf J, Deibler K, Hogendorf WF, Bau S, Glendorf T, Stidsen CE, et al

Factors to consider include the method of consumption (smoking, vaping, edibles), frequency of use, the presence of other medical conditions, and concurrent medications

Semaglutide was shown to be effective at reducing glucose levels and body weight with once-weekly s.c