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This conclusion is consistent with an at least similarly high expression of most enzymes involved in oxidative metabolism of glucose in astrocytic as in neuronal cell fractions freshly obtained from the mouse brain (Lovatt et al., 2007)

Protein oxidation is another critical mechanism where free radicals modify amino acid side chains, form protein-protein cross-links, and fragment peptide chains

Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteins

doi: 10.1080/21655979.2021.2000742 100 ScottDLWolfeFHuizingaTW

Nonetheless, it did lower ALT levels in subjects with elevated baseline levels