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Zhang Q, Li Y, Zhu Q, Xie T, Xiao Y, Zhang F

3 Results 3.1 Uptake of exendin-4 in rats In order for peptides to be delivered by the Axcess formulation, the combination of API and excipients needs to pass through the stomach in an enteric-coated capsule, to prevent dilution or damage to the formulation, by acid conditions in the stomach

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This results in a surge of O 2 and opening of the mitochondrial permeability transition pore, triggering collapse of the mitochondrial membrane potential, release of pro-apoptotic factors, and massive hepatocyte necroptosis [367]