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Similar content being viewed by others Main The transcription factor nuclear factor E2-related factor 2 (NRF2) is an attractive therapeutic target because its activation stimulates a panoply of antioxidants that naturally resolve oxidative stress, a process central to diseases with great societal burden 1,2,3,4
Key steps to reducing risk: 1 Ask EVERY patient if they are taking a GLP-1 RA
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First, identifying and targeting patients with an active inflammatory-fibrotic phenotype, typically characterized by elevated baseline IL-6 or high-sensitivity C-reactive protein, or by MRI-PDFF-evidenced steatosis with elevated T1 mapping values
It relies on an enzyme named glutathione peroxidase to facilitate its role in reducing free radicals
