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The COX15 p.R217W mutation is associated with lactic acidosis, ataxia, and hypotonia, with epilepsy occurring in 71.4% of cases
This could theoretically oppose tirzepatide's glucose-lowering effects
The pivotal trial randomized 412 HIV-infected patients with abdominal fat accumulation to 2 mg of subcutaneous tesamorelin daily or placebo for 26 weeks, in a double-blind, placebo-controlled design
The study found that ipamorelin 0.03-mg/kg twice daily for up to 7 days was well tolerated [16]
It works best paired with steady sleep, protein, and training, not on its own
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