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Microdosing is not appropriate for every patient, and splitting doses changes the pharmacokinetic profile of the medication in ways that require medical oversight

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Notably, these effects were not mimicked by E alone, which failed to rescue cycle perturbations and had a discernible uterotrophic action, but were replicated, in terms of reversal of irregularities of the ovarian cycle, by GLP1 alone, which nonetheless did not elevate LH levels

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