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Additionally, the liver has a dual supply of blood from both arterial and venous sources (approximately by a 30/70 ratio) which makes estimation of an input signal for PET kinetic modelling challenging

Semaglutide's gastrointestinal side effectsnausea, vomiting, and diarrheacan lead to dehydration if fluid intake is inadequate

Alcohol also lowers inhibition around food choices, which can undermine the dietary changes GLP-1 is supposed to make easier

Although rates of adverse effects differ between specific agents, the most common adverse effects with the GLP- 1 RA class are gastrointestinal (GI)related

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Long-term use of medications like proton pump inhibitors (PPIs) and metformin[16], which can reduce B12 absorption