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Prior to analysis, the XFe96 instrument (Seahorse Biosciences, North Billerica, MA, USA) mixed the assay media in each well for 10 minutes to allow the oxygen partial pressure to reach equilibrium
After 714 days of daily dosing, likely due to receptor desensitization
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To be more specific, MMs with KIT mutations in exon 11 (L576P) and exon 13 (K642E) tend to have a better and longer response to C-KIT inhibitors than other mutations (84, 151)
Back, Neck, and Nerve Pain Spinal discs are tough places for standard stem cells to survive