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46,47 Germline mutations in the LKB1 gene are associated with Peutz-Jeghers syndrome

Fragment 176-191, closely related to AOD-9604, uses similar dosing ranges

PMID: 29155147): 5-Amino-1MQ showed NNMT selectivity with IC50 of 1.2 microM Reduced body weight and white adipose mass in diet-induced obese mice over 11 days No effect on food intake, suggesting metabolic rather than appetitive mechanism Nicotinamide N-methyltransferase inhibition mimics and boosts exercise-mediated improvements in muscle function in aged mice , published in Scientific Reports (Dimet-Wiley AL et al., 2024

[PMID: 3107976] PubMed record related to this compound for laboratory literature review

They have a higher fibroproliferative capacity and can divide in vitro without the need for extra growth factors

Gynecol Oncol (2005) 97(3):8708