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TRIUMPH-3 (1,949 patients with obesity and established cardiovascular disease) showed up to 22.6% weight loss at 80 weeks, plus meaningful improvements in triglycerides, blood pressure, and inflammatory markers
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For example, sub-mental fullness (fat under the chin)
Cell Rep 21(5):11601168
Federal Reg
Some lean mass loss is expected with any significant weight reduction
This might relate to GIPs potential effects on food reward pathways or metabolic signaling
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