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Both agents target glucose homeostasis through different mechanismsberberine activates AMPK and improves insulin sensitivity, while GLP-1 agonists enhance insulin secretion and slow gastric emptying, creating potential synergy rather than direct antagonism

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However, in patients with heart failure with reduced ejection fraction (HFrEF), RAASi therapies significantly reduce mortality, and their withdrawal or underdosing may adversely impact outcomes [56]

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Notable nightshade members are potatoes, tomatoes, chili peppers, goji berries and even tobacco