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He views this as part of comprehensive hormone optimization for a man in his fifties who wants to maintain peak performance

Esposito, Feasibility of simplification from a basal-bolus insulin regimen to a fixed-ratio formulation of basal insulin plus a GLP-1RA or to basal insulin plus an SGLT2 inhibitor: BEYOND, a randomized, pragmatic trial

The frequency of NAION in the analyses ranged from 0.07% to 0.24%