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On average, the patients lost 17.5% of their body weight at 24 weeks and 24.2% of weight after 48 weeks

Congratulations to the authors

Abramson, A

The Long-Term Adjustment For the majority of individuals, the body undergoes a period of habituation. This means your brain and gut eventually get used to the presence of the medication

It can also interact with other medications, including antidepressants and certain antacids, potentially affecting how well it works or increasing side effects