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160162, 2000 [58] R
Methylcobalamin may rarely cause overstimulation or vivid dreams
In mouse models of highfat dietinduced liver steatosis, it significantly inhibits hepatic NNMT activity, reduces NAM methylation, increases NAD+ and SAM levels, enhances mitochondrial fatty acid oxidation, reduces hepatic triglyceride and lipid accumulation, lowers lipotoxicity markers (e.g., malondialdehyde, transaminases), improves hepatocellular injury, and reverses steatosis
A potential future avenue includes long-acting analogues of LEAP2, a native antagonist of the ghrelin receptor, which may reduce food intake by attenuating ghrelin-mediated orexigenic and lipogenic signaling
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