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For example, intake of any substance that causes more work for your liver including medications and alcohol depletes glutathione
Molecules 26 (21), 6456
Even if it is still unclear whether OS is a primary or a secondary cause of neurodegeneration in ALS, overwhelming evidence indicates the pathological role of OS, and alterations in KEAP1 and NRF2 expression and in KEAP1-NRF2 activity may explain the progressive MN degeneration and death associated with ALS [170]
Hence, whether deletion of NOX improves survival of SOD1 G93A mice remains unclear
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