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Drug-induced acute liver failure is a fatal disease thats caused by the toxic metabolite N-acetyl-p-benzoquinone-imine that leads to glutathione depletion

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Saleh EM, El-awady RA, Eissa NA, Abdel-Rahman WM

2.14 Animal model and experimental protocol 2.14.1 Establishment of ischemia-reperfusion mouse model and drug administration protocol Mice (C57BL/6 strain) were housed under controlled environmental conditions with a 12-hour light/dark cycle and ad libitum access to standard rodent chow and water