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Abbreviations ROS: Reactive Oxygen Species NAC: N-acetyl-L-cysteine TSPCs: Tendon Stem/Progenitor Cells COL1A1: Collagen Type 1 Alpha 1 TNC: Tenascin C SCX: Scleraxis TNMD: Tenomodulin PI3K: Phosphoinositide 3-kinase ECM: Extracellular Matrix OS: Oxidative Stress ROS: Reactive Oxygen Species CCK-8: Cell Counting Kit-8 H 2 O 2 : Hydrogen Peroxide AMI: Arithmetic Means Intensity PBS: Phosphate-Buffered Saline MFI: Mean Fluorescence Intensity SDS: Sodium Dodecyl Sulfate HRP: Horseradish Peroxidase SD: Standard Deviation DEGs: Differentially expressed genes GO: Gene Ontology BP: Biological Process MF: Molecular Function CC: Cellular Component References Pillai DS, Dhinsa BS, Khan WS

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The substances still arent approved for any specific medical condition, and any current use remains off-label, meaning a doctor is prescribing or recommending something outside its formally approved purpose