obesity + T2D, highest dose: Retatrutide: 28.3% 20.8% Semaglutide 7.2 mg: 20.7% 14.1% Orforglipron: 12.4% 10.5% Placebo-adjusted, retatrutide 12 mg delivered about two-thirds of the effect in type 2 diabetes that it delivered in the non-diabetic TRIUMPH-1 cohort 16.8 points versus 26.1 points
Just resume your dose as soon as you can, following your regular schedule
Interactions may occur during or within 14 days following the use of monoamine oxidase (MAO) inhibitors, sympathomimetics, alcohol, adrenergic neuron-blocking drugs, and possibly some anesthetic agents
The drug could also be administered orally, which comes with its own caveats
Most people start seeing weight loss within the first few weeks of treatment with tirzepatide and semaglutide
Zhang B, Upadhyay R, Hao Y, Samanovic MI, Herati RS, Blair JD, et al