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In contrast, studies of long-term administration report weaker or absent modulation of these circuits, suggesting that neural adaptations may normalize with sustained exposure or that acute effects reflect transient pharmacodynamic responses rather than stable neuroplastic changes

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Nrf2 is also a metabolic regulator with roles in key pathways including NADPH metabolism, the pentose phosphate pathway (PPP), and nucleotide synthesis, all of which have been implicated in promoting tumorigenesis 70

They just started May 30th with just starting the Phase three trials