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Perspective on the Rx Pipeline: Diabetes and GLP-1 Agonists Situation Summary Initial therapy for individuals with T2DM who are at high risk for CVD, heart failure (HF) and/or chronic kidney disease is metformin and a glucagon-like peptide 1 (GLP-1) or sodium glucose transporter ligand 2 (SGLT-2)

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15 Cardiovascular Outcomes Both SGLT2 inhibitors and GLP-1 receptor agonists improve cardiovascular outcomes in patients with T2DM, but the nature and extent of these benefits differ between the 2 drug classes

These results were observed in patients with T2DM who were inadequately controlled by diet and exercise alone and who had no prior experience with injectable diabetes therapy [70]