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If your medication has a warning not to eat grapefruit while taking it, you shouldnt take berberine with it, either.55 (Note, also, that berberine isnt the only supplement that interacts with cytochrome P450)

Synergistic combinations with immunotherapy, radiotherapy or ferroptosis-inducing agents also hold strong potential

rare but serious reactions include anaphylaxis and hypokalaemia during initial treatment

However, this is very important: enthusiastic anecdotal reports are not a substitute for controlled clinical trials

2. May improve psoriasis

On the other hand, those with methylation issues (MTHFR gene mutations carriers, for instance) do best on methylated B12, that is, methylcobalamin