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Campolo et al., 2017
Additionally, differences in volume and abnormal functional responses have been observed in autism across these cortical brain regions (SM1(Kleijer et al., 2018), mPFC(Courchesne et al., 2011
Furthermore, the well documented efficacy of combined folic acid, B6, and B12-vitamin supplementation to reduce hyperhomocysteinemia could enhance GSH activity and reduce oxidative stress (161)
Techniques such as fluorimetry, bioluminometery, HPLC and LC/MS have so far been used to detect and quantify different forms of GSH in biological samples 8
Since cysteine is known to be neurotoxic in excessive amounts [32], treatment with N-acetylcysteine should not be recommended for patients with glutathione synthetase deficiency as this may increase the intracellular cysteine levels even more
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