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The densities of IPT3 and IPT4 domains of two c-MET molecules were completely unresolved in this cryo-EM map, presumably due to structural flexibility

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Oral antidiabetic drugs remain the cornerstone of therapy for type 2 diabetes mellitus however, conventional immediate release formulations often suffer from short biological half lives, frequent dosing requirements, fluctuating plasma drug concentrations, and reduced patient compliance

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However, we do not say that tirzepatide directly increases energy expenditure, because this is not yet fully confirmed in human studies