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While severe hypoglycemia is uncommon with tirzepatide monotherapy due to its glucose-dependent mechanism, combining it with other glucose-lowering agents or supplements increases risk

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Chavarro JE, Rich-Edwards JW, Rosner BA, Willett WC

Firstly , it stimulates insulin secretion from pancreatic beta cells in a glucose-dependent manner, meaning insulin release occurs primarily when blood glucose levels are elevated

(PubMed) Iyer R, Gupta A, Khan A, Hiremath S, Lokhandwala Y

Optimizing the use of glucagon-like peptide 1 receptor agonists in type 2 diabetes: executive summary