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B12 shots are beneficial for individuals whose bodies have difficulty absorbing the vitamin through oral supplements due to a lack of intrinsic factor

This means that hydroxycobalamin stays in the body for longer periods of time and can provide sustained levels of vitamin B12, which may be beneficial for individuals with severe or chronic vitamin B12 deficiency

If you are pregnant or breastfeeding

Because they are so effective, injections are a reliable way to manage a deficiency and avoid common treatment pitfalls that can occur when absorption is a problem

[58] The dose studied for Hashimotos is around 600 mg per day, while higher doses have been used for OCD and PCOS

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