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Recently completed CARMELINA and CAROLINA trials also suggested that linagliptin did not increase HF hospitalization compared to placebo or glimepiride [57, 58]
73 In patients with reflux-predominant symptoms unresponsive to lifestyle modification, proton pump inhibitors or histamine-2 receptor antagonists may be used
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However, in disease states, this interaction may turn maladaptive, promoting inflammation and neurodegeneration
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