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Accordingly, the RIG-I pathway decreases, and the immune defense mechanism shifts to the activated TLR3, TLR7, TLR8, TLR9, MDA5, and UPS pathways found in neutrophil, macrophage, and dendritic cells
The new insight in the pathogenesis has given a number of new targets for intervention
doi: 10.3389/fmed.2016.00038 Received 03 July 2016 Accepted 09 August 2016 Published 23 August 2016 Volume 3 - 2016 Edited by Mohammed Morad, Clalit Health Services, Israel Reviewed by Luciana Hannibal, University Medical Center Freiburg, Germany
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Najmi A, Wang S, Huang Y, Seefeldt T, Alqahtani Y, Guan X
These drugs may lower inflammatory markers including C-reactive protein, TNF-, IL-6, and IL-1 through direct receptor activation and indirect metabolic improvements
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