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Third axis, genome-wide transcriptional modulation

Evidence Gap Long-term (multi-year) outcomes data is still maturing

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Arroyave-Ospina JC, Wu Z, Geng Y, Moshage H (2021) Role of oxidative stress in the pathogenesis of non-alcoholic fatty liver disease: implications for prevention and therapy

Always undergo a blood test or medical screening if you plan on long-term, high-dose therapy

Nevertheless, because endogenous oxyntomodulin is currently not believed to play a major role in regulating metabolic processes (55), it seems unlikely that cleavage of oxyntomodulin by DPP-4 would be associated with significant effects under normal physiological circumstances