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All other evidence is from rodent and in vitro models
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Vitamin B12 is a nutritional aid that keeps blood and nerve tissues healthy and helps to generate DNA, the gene of every cell
Transsulfuration Pathway: Uniquely upregulates the transsulfuration pathway (via cystathionine -synthase), enhancing protection against reactive oxygen species (ROS) via glutathione synthesis
Hydroxocobalamin 1mg is the standard UK formulation, typically administered every two to three months for maintenance therapy Self-administration requires GP prescription, competency training from practice nurses, and demonstration of proper injection technique Common injection sites include the thigh (vastus lateralis) for both intramuscular and subcutaneous administration with site rotation essential Serious side effects are rare but anaphylaxis requires immediate 999 call
Biophys J (2016) 110:202633
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