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Reestablishing the cellular metabolic homeostasis in inflammatory diseases as well as SARS-CoV-2 infection and COVID-19 disease especially in the lungs and cardiovascular system, could become paramount to balance altered innate and adaptive immunity and cell function and reduce morbimortality (333335)

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described a case of rapid progression in a patient with a BCS1L mutation, characterized by growth retardation, epileptic spasms, and frequent seizures in later stages