and Metabolism 87 (3), 12391246
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Hypoglycaemia : Retatrutide itself did not cause significant hypoglycaemia in Phase 2 trials
Short-Term Effects (13 Weeks) Reduced fatigue and sluggishness Enhanced mental focus and memory Improved mood and motivation During this period, the body continues to absorb B12, and the cumulative effects become more noticeable
Interestingly, this reduced movement phenotype can be restored by blocking the GLP-1R pharmacologically or by disrupting subdiaphragmatic vagal signaling [123]
While current studies demonstrate promising results, understanding the long-term effects of GLP-1 receptor agonists will be crucial for establishing their role in chronic obesity management