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109 UCP1 also mediated the uptake of succinate from the circulation by BAT and WAT, thereby reducing extracellular succinate, which activated succinate receptor 1 in HSCs and macrophages to produce pro-inflammatory effects

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Increased expression of MMP-9 was detected around the tumor capsule in HCC and was strongly correlated with tumor size, capsule status, tumor stage, and HCC recurrence risk (Arii et al., 1996

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What Berberine Research Does NOT Demonstrate Responsible evaluation of berberine requires acknowledging the boundaries of current evidence : Research has not established berberine as a substitute for prescription medications Weight outcomes vary significantly among individuals Effects observed in study conditions may not replicate in all real-world scenarios Transdermal delivery of berberine specifically requires additional research Most clinical studies examined oral berberine