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Treating obesity with behavior change, generic anti-obesity medications, and GLP-1 seems to reduce the risk profile associated with all of these [cardiometabolic] diseases, Frank added

Congenital Problems Sometimes babies are born without a thyroid gland or with a deformed gland, which results in reduced thyroid function

However, the research does not establish that these medications directly prevent or treat addiction

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Other concerning symptoms that necessitate medical consultation include: Severe abdominal distension or inability to pass gas/stool (possible ileus or bowel obstruction) Nausea that worsens rather than improves after 812 weeks Inability to maintain adequate nutrition or hydration Unintentional weight loss exceeding clinical targets New or worsening heartburn or reflux symptoms Visual changes (especially with rapid blood sugar improvement) Severe headache or altered mental status Signs of gallbladder disease (right upper quadrant pain, especially after eating) Hypoglycemia symptoms if taking insulin or sulfonylureas Patients should generally not discontinue GLP-1 medications without medical guidance, except in emergencies such as suspected pancreatitis or severe allergic reaction

Numerous metabolic complications, including but not limited to increased cardiovascular risk, hypertension, dyslipidemia, obstructive sleep apnea, and non-alcoholic fatty liver disease (NAFLD), are commonly observed in individuals with both obesity and T2D (3, 4)