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In diet-induced obese (DIO) mouse models, 5-Amino-1MQ treatment produced significant reductions in body weight, white adipose tissue mass, and adipocyte cell size without significant effects on food intake suggesting a metabolic rather than appetite-suppressing mechanism
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Liu Y, Gao Y, Liu Y, Zhang Y, Wang S, Yu B
study, mice treated with MOTS-c (5 mg/kg/day IP for 7 days) showed improved glucose disposal with no reported adverse effects on body weight, organ histology, or behavior [2]