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Furthermore, both astrocytes and neurons can use microglia-derived quinolinic acid as an alternative source to replenish NAD stores (206, 207)

The goal is not to eliminate exercise-induced oxidative stress entirely, which would potentially impair training adaptations, but to ensure that antioxidant defenses remain adequate to prevent excessive cellular damage while allowing beneficial adaptive signaling to occur

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The research ethics committee of the School of Medicine, Tohoku University, approved this study, which was conducted in accordance with the ethical guidelines of the 1975 Declaration of Helsinki

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