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To date, tens of thousands of research participants have received GLP-1RAs in RCTs investigating efficacy for improving glycemic control, body weight, and cardiovascular outcomes

In this study, the difference in body weight reduction between tirzepatide- and semaglutide-treated groups can only partly explain the improvement in insulin sensitivity, lending support to the observation that tirzepatide was associated with improvements in insulin sensitivity associated with both body weight-lowering and a potential insulin-sensitizing effects of GIP