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It is advised to apply once per day, in the morning

Berg AH, Combs TP, Scherer PE

GLP-1 therapies influence pathways tied to addiction and reward, according to the Endocrine Society A randomized clinical trial published in JAMA Psychiatry found semaglutide reduced alcohol cravings and consumption Users commonly report: Reduced desire to drink Feeling full faster when drinking Less reward from alcohol The data: early, but directionally consistent While long-term industry sales data is still developing, the early signals from clinical studies, observational research, and population polling all point in the same direction: GLP-1 use is associated with lower alcohol consumption for at least some users

In June 2025, Amgen announced positive Phase 2 trial results for MariTide showing up to ~20% weight loss in obese patients and ~17% in type 2 diabetes patients, presented at the ADA 85th scientific sessions

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