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Reference lists of included studies and relevant reviews were screened manually to identify additional eligible studies

In these situations, patients may have high B12 on blood work but still exhibit neurological symptoms of deficiency (tingling, numbness, cognitive changes)

5-Amino-1MQ may appear red, reddish, orange, or deep-colored depending on the batch and raw material presentation

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THP-1 cells were differentiated by treatment with 100 nM phorbol 12-myristate 13-acetate (PMA) (Sigma Aldrich)

In rare cases, some people may experience an allergic reaction to I-VIT 12 Injection